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CYP1A2 polymorphism and theophylline clearance in Korean non-smoking asthmatics

机译：韩国非吸烟哮喘患者CYP1A2基因多态性与茶碱清除率的关系

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BackgroundTheophylline is mainly metabolized by cytochrome P450 (CYP) 1A2 and CYP2E1 which show inter-individual variations. However, the underlying mechanism remains unknown in humans. We investigated the relationship between differences in theophylline clearance and genetic polymorphisms in the CYP1A2 and CYP2E1 gene in 89 Korean asthmatic patients.

机译：背景茶碱主要通过细胞色素P450（CYP）1A2和CYP2E1代谢，这些色素之间存在个体差异。但是，其基本机制在人类中仍然未知。我们调查了89例韩国哮喘患者茶碱清除率差异与CYP1A2和CYP2E1基因遗传多态性之间的关系。

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期刊名称 Asia Pacific Allergy
作者
Eun-Young Yim; Hye-Ryun Kang; Jae-Woo Jung; Seong-Wook Sohn; Sang-Heon Cho;
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作者单位

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年(卷),期 2013(3),4
年度 2013
页码 231–240
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
Theophylline Cytochrome P450 CYP1A2 Polymorphism Clearance Electrophoretic mobility shift assay;

机译：茶碱;细胞色素P450;CYP1A2;多态性;清除率;电泳迁移率变动分析;

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专利

1. Association between common CYP1A2 polymorphisms and theophylline metabolism in non-smoking healthy volunteers. [J] . Liqing Wang, Zheyi Hu, Xun Deng, Basic & clinical pharmacology & toxicology. . 2013,第4期

机译：非吸烟健康志愿者中常见的CYP1A2多态性与茶碱代谢之间的关联。
2. The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients [J] . Uslu A, Ogus C, Ozdemir T, BMB Reports . 2010,第8期

机译：CYP1A2基因多态性对土耳其患者茶碱代谢和慢性阻塞性肺疾病的影响
3. The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients [J] . Ahmet Uslu, Candan Ogus, Tulay Ozdemir, BMB Reports . 2010,第8期

机译：CYP1A2基因多态性对土耳其患者茶碱代谢和慢性阻塞性肺病的影响
4. Association of the daily ratio of FEV1 to FVC with the real-time exposure level to indoor PM2.5 and C02 after controlling for other risk factors in adult non-smoking refractory asthmatics in urban areas of South Korea: Results from Environmental Health St [C] . Sol Yu, Sujung Park, Jungeun Lee, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：在控制韩国城市成人非吸烟难治性哮喘患者的其他危险因素后，FEV1与FVC的每日比率与室内PM2.5和CO2实时暴露水平的关联：Environmental Health St的结果
5. The G894-T894 exon 7 polymorphism in the endothelial nitric oxide synthase gene and blood pressure in a cohort of lead -exposed workers from Korea. [D] . Lustberg, Mark E. 2002

机译：一组来自韩国的铅暴露工人中，内皮一氧化氮合酶基因的G894-T894外显子7多态性与血压。
6. The Impact of CYP1A2 and CYP2E1 Genes Polymorphism on Theophylline Response [O] . Em Sutrisna 2016

机译：CYP1A2和CYP2E1基因多态性对茶碱反应的影响
7. The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients [O] . Ahmet Uslu, Candan Ogus, Tulay Ozdemir, 2010

机译：CYP1A2基因多态性对土耳其患者茶碱代谢和慢性阻塞性肺病的影响

CYP1A2 polymorphism and theophylline clearance in Korean non-smoking asthmatics

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