The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats

摘要

BackgroundEpidural fibrosis often causes serious complications in patients after lumbar laminectomy and discectomy and is associated with the proliferation of fibroblasts. Suramin is known to have an obvious inhibitory effect on the coactions of many growth factors and their receptors, but little was previously known about the effect of suramin on fibroblast proliferation and the progress of epidural fibrosis.