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Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies

机译：高加索和亚洲人群中GDF5 + 104T / C多态性与膝骨关节炎之间的关联：基于病例对照研究的荟萃分析

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BackgroundOsteoarthritis (OA) is a degenerative joint disease with a complex genetic background. Variants in growth differentiation factor 5 (GDF5) have been reported to be associated with rheumatoid arthritis (RA) in several ethnic populations. The present study aimed to assess the association between the GDF5 +104T/C polymorphism and the susceptibility of the knee to OA through a meta-analysis of available case-control studies.

机译：背景骨关节炎（OA）是一种具有复杂遗传背景的变性关节疾病。据报道，在一些种族人群中，生长分化因子5（GDF5）的变异与类风湿关节炎（RA）有关。本研究旨在通过对现有病例对照研究的荟萃分析来评估GDF5 + 104T / C多态性与膝盖对OA的敏感性之间的关联。

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期刊名称 Journal of Orthopaedic Surgery and Research
作者
Dong Jiang; Zengtao Hao; Dongsheng Fan; Wen Guo; Pengcheng Xu; Chao Yin; Shuzheng Wen; Jihong Wang;
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作者单位

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年(卷),期 2016(11),-1
年度 2016
页码 104
总页数 7
原文格式 PDF
正文语种
中图分类矫形学;
关键词
Meta-analysis Osteoarthritis Polymorphism GDF5;

机译：荟萃分析;骨关节炎;多态性;GDF5;

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专利

1. Association between the +104T/C polymorphism in the 5′UTR of GDF5 and susceptibility to knee osteoarthritis: A meta-analysis [J] . HaoS.-W., JinQ.-H. Molecular medicine reports . 2013,第2期

机译：GDF5 5'UTR中+ 104T / C多态性与膝骨关节炎易感性的关联：一项荟萃分析
2. Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects [J] . Feng Pan, Jing Tian, Tania Winzenberg, BMC Musculoskeletal Disorders . 2014,第1期

机译：GDF5 rs143383基因多态性与膝骨关节炎之间的关联：基于23,995名受试者的最新荟萃分析
3. Evidence of association between GDF5 polymorphisms and congenital dislocation of the hip in a Caucasian population. [J] . Rouault K, Scotet V, Autret S, Osteoarthritis and cartilage . 2010,第9期

机译：GDF5基因多态性与高加索人群髋部先天性脱位之间存在关联的证据。
4. Association of PS1 Gene Polymorphisms with Alzheimer's Disease in Chinese Population: A Meta-Analysis of Case-Control Studies [C] . Yaodong Zhang, Yong Xu, Hongwei Nei Information technology and agricultural engineering . 2011

机译：PS1基因多态性与中国人群阿尔茨海默氏病的关联：病例对照研究的荟萃分析
5. Associations of lung and upper aero-digestive tract (UADT) cancers with environmental factors, genetic polymorphisms, and tumor biomarkers in a population-based case-control study. [D] . Oh, Sam Seung-Hoon. 2010

机译：在一项基于人群的病例对照研究中，肺癌和上消化道（UADT）癌症与环境因素，遗传多态性和肿瘤生物标志物的关联。
6. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis [O] . Dongquan Shi, Takahiro Nakamura, Masahiro Nakajima, 2008

机译：RHOB和TXNDC3中单核苷酸多态性与膝骨关节炎易感性的关系：东亚人群的两个病例对照研究和一项荟萃分析
7. Association between polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies [O] . 2016

机译：高加索和亚洲人群多态性与膝骨关节炎之间的关联：基于病例对照研究的荟萃分析

Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies

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