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Effects of Repeated Administration of 34-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus

机译：重复给药34-亚甲二氧基甲基苯丙胺（MDMA）对大鼠海马回避记忆和细胞密度的影响

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IntroductionMDMA or ecstasy is a derivative of amphetamines used mostly by young people worldwide. Although the acute effects of this drug are known, the effect of chronic administration is not well studied. Therefor the aim of this study was to determine the effects of repeated (long term) administration of MDMA on rats’ memory and their hippocampal cell density.

机译：简介摇头丸或摇头丸是苯丙胺的衍生物，主要被全世界的年轻人使用。尽管该药物的急性作用是已知的，但长期服用的作用尚未得到很好的研究。因此，本研究的目的是确定重复（长期）施用MDMA对大鼠记忆力及其海马细胞密度的影响。

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期刊名称 Basic and Clinical Neuroscience
作者
Mehrdad Jahanshahi; Kamran Haidari; Simin Mahaki-Zadeh; EmseGol Nikmahzar; Fatemeh Babakordi;
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作者单位

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年(卷),期 2013(4),1
年度 2013
页码 57–63
总页数 7
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Ecstasy Neurons Astrocytes Passive Avoidance Memory;

机译：摇头丸;神经元;星形胶质细胞;被动回避记忆;

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专利

1. In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function. [J] . Callaghan PD, Owens WA, Javors MA, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2007,第3期

机译：体内对大鼠海马中5-羟色胺清除率的分析表明，重复施用对甲氧基苯丙胺（PMA）而不是3,4-亚甲二氧基甲苯丙胺（MDMA）会导致5-羟色胺转运蛋白功能的长期缺陷。
2. Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3?weeks after MDMA administration in Dark Agouti rats [J] . Peter Petschner, Viola Tamasi, Csaba Adori, BMC Genomics . 2018,第1期

机译：基因表达分析表明海马中的记忆力和认知功能降低，并增加了正面皮质3中的突触重组在黑暗agouti大鼠MDMA施用后的突触重组
3. Retraction Note to: Gene expression analysis indicates CB1 receptor upregulation in the hippocampus and neurotoxic effects in the frontal cortex 3?weeks after single-dose MDMA administration in Dark Agouti rats [J] . Peter Petschner, Viola Tamasi, Csaba Adori, BMC Genomics . 2016,第1期

机译：撤消注意：基因表达分析表明，在黑暗Agouti大鼠中单剂量MDMA给药3周后，海马CB1受体上调和额叶皮层的神经毒性作用
4. Highly polysialylated neural cell adhesion molecule positive cells increased and changed localization in rat hippocampus with exposure to repeated kindled seizures [C] . K. Sato, M. Iwai, W.R. Zhang, International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia . 2003

机译：高度多糖化的神经细胞粘附分子阳性细胞增加并改变了大鼠海马的定位，暴露于反复点燃癫痫发作
5. The effects of repeated ketamine administration in rats on reversal, extinction, and working memory tasks in the Morris water maze. [D] . Wise, Laura E. 2004

机译：大鼠反复服用氯胺酮对莫里斯水迷宫中逆转，灭绝和工作记忆的作用。
6. Tolerance to the locomotor-activating effects of 34-methylenedioxymethamphetamine (MDMA) predicts escalation of MDMA self-administration and cue-induced reinstatement of MDMA seeking in rats [O] . Kevin T. Ball, Mylissa Slane -1

机译：对34-亚甲基二氧基甲基苯丙胺（MDMA）的运动激活作用的耐受性预示着MDMA自我给药的增强和提示诱导的MDMA寻找的恢复
7. Effects of repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) on avoidance memory and cell density in rats' hippocampus [O] . Jahanshahi M., Haidari K., Mahaki-Zadeh S., 2013

机译：重复给药3,4-亚甲二氧基甲基苯丙胺（MDMA）对大鼠海马回避记忆和细胞密度的影响
8. Glutamate Receptor Pathology is Present in the Hippocampus Following Repeated Sub-Lethal Soman Exposure in the Absence of Spatial Memory Deficits [R] . Johnson, E. A., Daugherty, K. S., Gallagher, S. J., 2008

机译：谷氨酸受体病理学在缺乏空间记忆缺陷后重复亚致死梭曼暴露后存在于海马中

Effects of Repeated Administration of 34-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus

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