Variation of fibrinogen oligosaccharide structure in the acute phase response: Possible haemorrhagic implications

摘要

BackgroundFibrinogen is an acute phase glycoprotein whose concentration increases in response to trauma. The newly synthesised protein is functionally enhanced and it is known that treatment with neuraminidase increases the rate of fibrin polymerisation. To explore this, we examined the differences between the oligosaccharide structures of quiescent and acute phase fibrinogen.