Serum HE4 CA125 YKL-40 bcl-2 cathepsin-L and prediction optimal debulking surgery response to chemotherapy in ovarian cancer

摘要

BackgroundThe most important prognostic factor in the ovarian cancer is optimal cytoreduction. The neoadjuvant chemotherapy, an only optional method of treatment in this case and is still the subject of debate. The object of this study was to evaluate the usefulness of markers: CA 125, HE4, YKL-40 and bcl-2 as well as cathepsin L in predicting optimal cytoreduction and response to chemotherapy.