A large animal neuropathic pain model in sheep: a strategy for improving the predictability of preclinical models for therapeutic development

摘要

BackgroundEvaluation of analgesics in large animals is a necessary step in the development of better pain medications or gene therapy prior to clinical trials. However, chronic neuropathic pain models in large animals are limited. To address this deficiency, we developed a neuropathic pain model in sheep, which shares many anatomical similarities in spine dimensions and cerebrospinal fluid volume as humans.