Stereodivergent approach in the protected glycal synthesis of L-vancosamine L-saccharosamine L-daunosamine and L-ristosamine involving a ring-closing metathesis step

摘要

In this paper, a new access to several chiral 3-aminoglycals as potential precursors for glycosylated natural products is reported from a common starting material, (−)-methyl-L-lactate. The stereodivergent strategy is based on the implementation of a ring-closing metathesis of vinyl ethers as key step of reaction sequences developed.