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The logic of equivalence testing and its use in laboratory medicine

机译:等效测试的逻辑及其在实验室医学中的应用

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摘要

Hypothesis testing is a methodological paradigm widely popularized outside the field of pure statistics, and nowadays more or less familiar to the largest part of biomedical researchers. Conversely, the equivalence testing is still somehow obscure and misunderstood, although it represents a conceptual mainstay for some biomedical fields like pharmacology. In order to appreciate the way it could suit laboratory medicine, it is necessary to understand the philosophy behind it, and in turn how it stemmed and differentiated along the history of classical hypothesis testing. Here we present the framework of equivalence testing, the various tests used to assess equivalence and discuss their applicability to laboratory medicine research and issues.
机译:假设检验是一种在纯粹统计学领域之外广泛流行的方法论范式,如今,大多数生物医学研究人员或多或少地熟悉了假设检验。相反,等效测试虽然在某些生物医学领域(例如药理学)上仍然是概念上的支柱,但仍在某种程度上仍然难以理解和理解。为了了解它适合实验室医学的方式,有必要了解其背后的哲学,以及它在经典假设检验的历史中如何产生和区分。在这里,我们介绍了等效性测试的框架,用于评估等效性的各种测试,并讨论了它们在实验室医学研究和问题中的适用性。

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