Sex impacts Th1 cells Tregs and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner

摘要

BackgroundMales and females have a different predisposition for the development of intestinal disorders, like inflammatory bowel disease (IBD). We hypothesized that sex specific differences in intestinal immune responses may underlie this bias. To test this hypothesis, we studied sex differences in immune cell populations in the Peyer’s patches (PP). For comparison with systemic immunity, we studied spleen cells.