Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO2) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO2 levels in a blood vessel phantom. DWP OCT SaO2 is linearly correlated with blood-gas SaO2 measurements. We demonstrate 6.3% precision in SaO2 levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO2 levels measured with DWP-OCT are identified and characterized.
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机译:离散血管中血红蛋白氧饱和度(SaO2)水平的非侵入式深度分辨测量可能对各种病理的诊断和治疗有影响。我们介绍了一种新颖的双波长光热(DWP)光学相干断层扫描(OCT),用于血管模型中SaO2水平的非侵入式深度分辨测量。 DWP OCT SaO2与血气SaO2测量值线性相关。我们展示了使用DWP-OCT在800和765 nm激发波长下测量的幻影血管测得的SaO2水平精确度为6.3%。鉴定并表征了用DWP-OCT测量的SaO2水平不确定性的来源。
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