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On the calculation of magnetic fields based on multipole modeling of focal biological current sources.

机译:关于基于聚焦生物电流源的多极建模的磁场计算。

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摘要

Spatially restricted biological current distributions, like the primary neuronal response in the human somatosensory cortex evoked by electric nerve stimulation, can be described adequately by a current multipole expansion. Here analytic formulas are derived for computing magnetic fields induced by current multipoles in terms of an nth-order derivative of the dipole field. The required differential operators are given in closed form for arbitrary order. The concept is realized in different forms for an expansion of the scalar as well as the dyadic Green's function, the latter allowing for separation of those multipolar source components that are electrically silent but magnetically detectable. The resulting formulas are generally applicable for current sources embedded in arbitrarily shaped volume conductors. By using neurophysiologically relevant source parameters, examples are provided for a spherical volume conductor with an analytically given dipole field. An analysis of the signal-to-noise ratio for multipole coefficients up to the octapolar term indicates that the lateral extent of cortical current sources can be detected by magnetoencephalographic recordings.
机译:空间受限的生物电流分布,如通过电神经刺激诱发的人体体感皮层中的初级神经元反应,可以通过电流多极扩展来充分描述。在此,根据偶极场的n阶导数,导出了用于计算当前多极感应磁场的解析公式。所需的差分运算符以封闭形式给出,用于任意顺序。该概念以不同的形式实现,以扩展标量和二进位格林函数,后者可以分离那些电性无声但可磁检测的多极源组件。所得公式通常适用于嵌入任意形状的体积导体中的电流源。通过使用神经生理学相关的源参数,提供了具有解析给定偶极场的球形体导体的示例。对高达八极项的多极系数的信噪比分析表明,脑磁记录可以检测到皮质电流源的横向范围。

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