BackgroundComputational methods for the prediction of protein features from sequence are a long-standing focus of bioinformatics. A key observation is that several protein features are closely inter-related, that is, they are conditioned on each other. Researchers invested a lot of effort into designing predictors that exploit this fact. Most existing methods leverage inter-feature constraints by including known (or predicted) correlated features as inputs to the predictor, thus conditioning the result.
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