mbs: modifying Hudsons ms software to generate samples of DNA sequences with a biallelic site under selection

摘要

BackgroundThe pattern of single nucleotide polymorphisms, or SNPs, contains a tremendous amount of information with respect to the mechanisms of the micro-evolutionary process of a species. The inference of the roles of these mechanisms, including natural selection, relies heavily on computer simulations. A coalescent simulation is extremely powerful in generating a large number of samples of DNA sequences from a population (species) when all mutations are neutral, and Hudson's >ms software is frequently used for this purpose.However, it has been difficult to incorporate natural selection into the coalescent framework.