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Monitoring the evolutionary aspect of the Gene Ontology to enhance predictability and usability

机译:监控基因本体论的进化方面以增强可预测性和可用性

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摘要

BackgroundMuch effort is currently made to develop the Gene Ontology (GO). Due to the dynamic nature of information it addresses, GO undergoes constant updates whose results are released at regular intervals as separate versions. Although there are a large number of computational tools to aid the development of GO, they are operating on a particular version of GO, making it difficult for GO curators to anticipate the full impact of particular changes along the time axis on a larger scale. We present a method for tapping into such an evolutionary aspect of GO, by making it possible to keep track of important temporal changes to any of the terms and relations of GO and by consequently making it possible to recognize associated trends.
机译:背景技术目前在开发基因本体论(GO)方面已经付出了很多努力。由于它所处理的信息具有动态性质,因此GO会进行不断的更新,其结果将以独立的版本定期发布。尽管有大量的计算工具可以帮助GO的开发,但是它们都在特定版本的GO上运行,这使得GO策展人很难在更大的范围内预期特定更改沿时间轴的全部影响。我们提出了一种方法,可以利用GO的这种进化方面,可以跟踪GO的任何术语和关系的重要时间变化,从而可以识别相关的趋势。

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