Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements

摘要

BackgroundTranscription factor binding to DNA requires both an appropriate binding element and suitably open chromatin, which together help to define regulatory elements within the genome. Current methods of identifying regulatory elements, such as promoters or enhancers, typically rely on sequence conservation, existing gene annotations or specific marks, such as histone modifications and p300 binding methods, each of which has its own biases.