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Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer

机译：选择性清除环境和内源性丝氨酸蛋白酶在大肠癌（DCC）和新生儿素中缺失的肿瘤抑制物：将饮食与癌症联系起来

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BackgroundThe related tumour suppressor proteins Deleted in Colorectal Cancer (DCC) and neogenin are absent or weakly expressed in many cancers, whereas their insertion into cells suppresses oncogenic behaviour. Serine proteases influence the initiation and progression of cancers although the mechanisms are unknown.

机译：背景技术在许多癌症中，缺失或表达的是在大肠癌（DCC）和新素中缺失的相关肿瘤抑制蛋白，而将其插入细胞则抑制了致癌行为。丝氨酸蛋白酶影响癌症的发生和发展，尽管其机制尚不清楚。

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期刊名称 BMC Cancer
作者
Caroline M. Forrest; Kara McNair; Maria C. J. Vincenten; L. Gail Darlington; Trevor W. Stone;
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作者单位

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年(卷),期 2016(16),-1
年度 2016
页码 772
总页数 19
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Deleted in colorectal cancer DCC Neogenin Serine proteases Chymotrypsin Subtilisin;

机译：在大肠癌;DCC;Neogenin;丝氨酸蛋白酶;胰凝乳蛋白酶;枯草杆菌蛋白酶中缺失;

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专利

1. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. [J] . J Vielmetter, J F Kayyem, J M Roman, Journal of cell biology . 1994,第6期

机译：新生神经元，一种在终末神经元分化过程中表达的禽细胞表面蛋白，与大肠癌中缺失的人类肿瘤抑制分子密切相关。
2. Loss of heterozygosity (LOH) of deleted in colorectal cancer (DCC) gene and predisposition to colorectal cancer: Significant association in colorectal cancer patients of Kashmir [J] . Nighat P. Khan, Arshad A. Pandith, Mahboob U. l. Hussain, Journal of Cancer Research and Experimental Oncology . 2011,第8期

机译：大肠癌（DCC）基因缺失的杂合性（LOH）的丧失和大肠癌的易感性：克什米尔大肠癌患者的重要关联
3. Deleted in Colorectal Cancer (DCC) pathfinding: Axon guidance gene finally turned tumor suppressor [J] . Duman-ScheelM. Current drug targets-The International journal for timely in-depth reviews on drug targets . 2012,第11期

机译：在大肠癌（DCC）寻路中删除：轴突导向基因终于变成了抑癌基因
4. Cancer-associated fibroblast expression of serine protease fibroblast activation protein increases tumour metastatic potential and alters cell death mechanisms [C] . Baird S.K., Rentier C., Smyth F.E Incorporating of the Australian Society for Biochemistry and Molecular Biology Combio . 2009

机译：丝氨酸蛋白酶成纤维细胞活化蛋白的癌症相关的成纤维细胞表达增加了肿瘤转移性潜力和改变细胞死亡机制
5. Structural and functional studies of axon guidance molecules: Netrin-1, deleted in colorectal cancer, and Semaphorin 3A. [D] . Minchenko, Maria. 2014

机译：轴突指导分子的结构和功能研究：在结肠直肠癌中缺失的Netrin-1和Semaphorin 3A。
6. Neogenin an avian cell surface protein expressed during terminal neuronal differentiation is closely related to the human tumor suppressor molecule deleted in colorectal cancer [O] . 1994

机译：Neogenin是一种在晚期神经元分化过程中表达的禽细胞表面蛋白与大肠癌中缺失的人类抑癌分子密切相关
7. Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer [O] . Caroline M. Forrest, Kara McNair, Maria C. J. Vincenten, 2016

机译：选择性清除环境和内源性丝氨酸蛋白酶在大肠癌（DCC）和新生儿素中缺失的肿瘤抑制物：将饮食与癌症联系起来
8. Prostasin Serine Protease as a Breast Cancer Invasion Marker and a Metastasis Suppressor [R] . Chai, K. X. , Chen, L. , Zhang, Y. 2006

机译：prostasin丝氨酸蛋白酶作为乳腺癌入侵标志物和转移抑制剂

Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer

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