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Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients

机译：在组织学上HER2阳性转移性乳腺癌患者中在循环肿瘤细胞上检测到的实时HER2状态预示了抗HER2治疗的不同结果

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摘要

BackgroundThis study was initiated to investigate the difference in HER2 status between tumor tissue and circulating tumor cells (CTCs), as well as the predictive value of CTC HER2 status for predicting the outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer (MBC) patients.

机译：背景本研究旨在调查肿瘤组织和循环肿瘤细胞（CTC）之间HER2状态的差异，以及CTC HER2状态对组织学上HER2阳性转移性乳腺癌的抗HER2治疗结果的预测价值（ MBC）患者。

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期刊名称 BMC Cancer
作者
Shaohua Zhang; Lei Li; Tao Wang; Li Bian; Haixu Hu; Chunhong Xu; Bing Liu; Yi Liu; Massimo Cristofanilli; Zefei Jiang;
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作者单位

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年(卷),期 2016(16),-1
年度 2016
页码 526
总页数 9
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Circulating Tumor Cells (CTCs) Human Epidermal Growth Factor Receptor 2 (HER2) Metastatic Breast Cancer (MBC) Anti-HER2 therapy Real-time HER2 status;

机译：循环肿瘤细胞（CTC）;人类表皮生长因子受体2（HER2）;转移性乳腺癌（MBC）;抗HER2治疗;实时HER2状态;

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专利

1. Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients [J] . Shaohua Zhang, Lei Li, Tao Wang, BMC Cancer . 2016,第1期

机译：在组织学上HER2阳性转移性乳腺癌患者中，在循环肿瘤细胞上检测到的实时HER2状态预示了抗HER2治疗的不同结果
2. Outcomes of HER2-positive non-metastatic breast cancer patients treated with anti-HER2 therapy without chemotherapy [J] . Nguy Susanna, Wu S. Peter, Oh Cheongeun, Breast cancer research and treatment. . 2021,第3期

机译：HER2阳性非转移性乳腺癌患者的结果，在没有化疗的情况下用抗HER2疗法治疗
3. Evaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy [J] . De Angelis Carmine, Nagi Chandandeep, Hoyt Cliff C., Clinical cancer research: an official journal of the American Association for Cancer Research . 2020,第3期

机译：评估肿瘤免疫浸润在患有Neoadjuvant抗Her2治疗的Her2阳性乳腺癌患者中的预测作用，无需化疗
4. Elevated WBP2 Expression in HER2-Positive Breast Cancers Correlates with Sensitivity to Trastuzumab-Based Neo-Adjuvant Therapy: A Retrospective and Multicentric Study [C] . Yoon Pin Lim International Molecular Medicine Tri-Conference. . 2019

机译：HER2阳性乳腺癌中的WBP2表达升高与基于曲妥珠单抗的新辅助治疗的敏感性相关：回顾性和多中心研究
5. A phase Ib study of safety and pharmacokinetics of trastuzumab emtansine and pertuzumab in Japanese patients with HER2-positive metastatic breast cancer [D] . NOGUCHI, Emi 2019

机译：Ib期研究曲妥珠单抗氨丹宁和帕妥珠单抗在日本HER2阳性转移性乳腺癌患者中的安全性和药代动力学
6. Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker [O] . Yi Liu, Qian Liu, Tao Wang, 2013

机译：HER2阳性转移性乳腺癌患者中的循环肿瘤细胞：有价值的预后和预测生物标志物
7. Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients [O] . 2016

机译：在组织学上HER2阳性转移性乳腺癌患者中，在循环肿瘤细胞上检测到的实时HER2状态预示了抗HER2治疗的不同结果

Real-time HER2 status detected on circulating tumor cells predicts different outcomes of anti-HER2 therapy in histologically HER2-positive metastatic breast cancer patients

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