RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression chromosomal status and epigenetic changes

摘要

BackgroundThe Ras Association Domain Family Member 1 (RASSF1) is one of the most frequently reported methylation-inactivated tumor suppressor genes in primary pancreatic ductal adenocarcinomas (PDAC). Limited information is still available about the impact of RASSF1 gene silencing on the expression of its different isoforms in neoplastic cells.