Genetic polymorphisms in CYP1A1 GSTM1 GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias

摘要

BackgroundMetabolic genes have been associated with the function of metabolizing and detoxifying environmental carcinogens. Polymorphisms present in these genes could lead to changes in their metabolizing and detoxifying ability and thus may contribute to individual susceptibility to different types of cancer. We investigated if the individual and/or combined modifying effects of the CYP1A1 MspI T6235C, GSTM1 presentull, GSTT1 presentull and GSTP1 Ile105Val polymorphisms are related to the risk of developing lung cancer in relation to tobacco consumption and occupation in Asturias, Northern Spain.