Changes in clot lysis levels of reteplase and streptokinase following continuous wave ultrasound exposure at ultrasound intensities following attenuation from the skull bone

摘要

BackgroundUltrasound (US) has been used to enhance thrombolytic therapy in the treatment of stroke. Considerable attenuation of US intensity is however noted if US is applied over the temporal bone. The aim of this study was therefore to explore possible changes in the effect of thrombolytic drugs during low-intensity, high-frequency continuous-wave ultrasound (CW-US) exposure.