首页> 美国卫生研究院文献>BMC Pharmacology Toxicology >Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

【2h】

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

机译：通过底物特异性和抑制剂结合定义的鼠类芳基胺N-乙酰基转移酶1型和人芳基胺N-乙酰基转移酶2型之间的差异

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundThe mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme with poor activity and human NATP is a pseudogene. (MOUSE)Nat2 is orthologous to (HUMAN)NAT1 and their corresponding proteins are functionally similar, but the relationship between (MOUSE)Nat1 and (HUMAN)NAT2 is less clear-cut.

机译：背景小鼠具有三个芳基胺N-乙酰基转移酶基因，（MOUSE）Nat1，（MOUSE）Nat2和（MOUSE）Nat3。这些被认为对应于人类中的（HUMAN）NAT1，（HUMAN）NAT2和NATP。（MOUSE）Nat3编码的酶活性差，而人NATP是假基因。（MOUSE）Nat2与（HUMAN）NAT1直系同源，并且它们的相应蛋白质在功能上相似，但是（MOUSE）Nat1与（HUMAN）NAT2之间的关系不那么清晰。

著录项

期刊名称 BMC Pharmacology Toxicology
作者
Nicola Laurieri; Akane Kawamura; Isaac M Westwood; Amy Varney; Elizabeth Morris; Angela J Russell; Lesley A Stanley; Edith Sim;
展开▼
作者单位

展开▼
年(卷),期 2014(15),-1
年度 2014
页码 68
总页数 13
原文格式 PDF
正文语种
中图分类药学;
关键词
Arylamine N-acetyltransferase (MOUSE)NAT1 (MOUSE)NAT2 Substrate specificity Inhibitor selectivity Structural docking;

机译：芳胺N-乙酰基转移酶;（MOUSE）NAT1;（MOUSE）NAT2;底物特异性;抑制剂选择性;结构对接;

相似文献

外文文献
中文文献
专利

1. Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. [J] . Russell AJ, Westwood IM, Crawford MH, Bioorganic and medicinal chemistry . 2009,第2期

机译：潜在乳腺癌标志物，人芳基胺N-乙酰基转移酶1及其鼠类同系物小鼠芳基胺N-乙酰基转移酶2的选择性小分子抑制剂。
2. Arylamine N-Acetyltransferases:Characterization of the Substrate Specificities and Molecular Interactions of Environmental Arylamines with Human NAT1 and NAT2 [J] . Li Liu, Annette Von Vett, Naixia Zhang Chemical research in toxicology . 2007,第9期

机译：芳胺N-乙酰基转移酶：底物特异性的表征和环境芳胺与人NAT1和NAT2的分子相互作用
3. A method for genotyping murine arylamine N-acetyltransferase type 2 (NAT2): a gene expressed in preimplantation embryonic stem cells encoding an enzyme acetylating the folate catabolite p-aminobenzoylglutamate. [J] . Payton M, Smelt V, Upton A, Biochemical Pharmacology . 1999,第5期

机译：一种对鼠类芳基胺N-乙酰基转移酶2型（NAT2）进行基因分型的方法：在植入前的胚胎干细胞中表达的一种基因，编码将叶酸分解代谢物对氨基苯甲酰谷氨酸乙酰化的酶。
4. QUANTIFICATION OF SUBSTRATE AND INHIBITOR BINDING TO WILD TYPE AND MUTANT ISOCITRATE DEHYDROGENASE (IDH1) BY NON-DENATURING MASS SPECTROMETRY [C] . Victor Mikhailov, Shuang Liu, Christopher Schofield, International Mass Spectrometry Conference . 2018

机译：通过非变性质谱法定量基质和抑制剂与野生型和突变体相酯脱氢酶（IDH1）的结合
5. Catalytic mechanism of the hamster arylamine N-acetyltransferase 2 (NAT2) and human histidine triad nucleotide binding protein 1 (HINT1). [D] . Zhou, Xin. 2010

机译：仓鼠芳胺N-乙酰基转移酶2（NAT2）和人组氨酸三联体核苷酸结合蛋白1（HINT1）的催化机理。
6. Genomic organization of human arylamine N-acetyltransferase Type I reveals alternative promoters that generate different 5′-UTR splice variants with altered translational activities [O] . Neville J. Butcher, Ajanthy Arulpragasam, Hui Li Goh, 2005

机译：人类I型芳基胺N-乙酰基转移酶的基因组组织揭示了可产生不同5-UTR剪接变体且翻译活性改变的启动子
7. Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding. [O] . Laurieri, N, Kawamura, A, Westwood, IM, 2014

机译：通过底物特异性和抑制剂结合确定鼠类芳基胺N-乙酰基转移酶1型和人芳基胺N-乙酰基转移酶2型之间的差异。

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

摘要

著录项

相似文献

相关主题

期刊订阅