Assessment of single-dose benzodiazepines on insulin secretion insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind placebo-controlled randomized cross-over trial ISRCTN08745124

摘要

BackgroundThe present study aimed at investigating in healthy volunteers the effects of diazepam and clonazepam on beta-cell function, insulin sensitivity and glucose effectiveness based on the frequently sampled intravenous (0.5 gkg^-1) glucose tolerance test with minimal-model analysis.