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Reduced representation bisulphite sequencing of ten bovine somatic tissues reveals DNA methylation patterns and their impacts on gene expression

机译：十个牛体细胞组织的亚硫酸氢盐代表性降低的测序揭示了DNA甲基化模式及其对基因表达的影响

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摘要

BackgroundAs a major epigenetic component, DNA methylation plays important functions in individual development and various diseases. DNA methylation has been well studied in human and model organisms, but only limited data exist in economically important animals like cattle.

机译：背景技术作为主要的表观遗传成分，DNA甲基化在个体发育和各种疾病中起着重要的作用。 DNA甲基化已在人类和模型生物中进行了充分研究，但在经济上重要的动物（如牛）中仅存在有限的数据。

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期刊名称 BMC Genomics
作者
Yang Zhou; Lingyang Xu; Derek M. Bickhart; El Hamidi abdel Hay; Steven G. Schroeder; Erin E. Connor; Leeson J. Alexander; Tad S. Sonstegard; Curtis P. Van Tassell; Hong Chen; George E. Liu;
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作者单位

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年(卷),期 2016(17),-1
年度 2016
页码 779
总页数 11
原文格式 PDF
正文语种
中图分类遗传学;应用微生物学;
关键词
Cattle genome Somatic tissue DNA methylation RRBS (reduced representation bisulphite sequencing);

机译：牛基因组;体细胞组织;DNA甲基化;RRBS（还原的亚硫酸氢盐测序）;

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专利

1. Reduced representation bisulphite sequencing of ten bovine somatic tissues reveals DNA methylation patterns and their impacts on gene expression [J] . Yang Zhou, Lingyang Xu, Derek M. Bickhart, BMC Genomics . 2016,第1期

机译：十个牛体细胞组织的亚硫酸氢盐递减表示法揭示了DNA甲基化模式及其对基因表达的影响
2. Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA. [J] . Korshunova Y, Maloney RK, Lakey N, Genome research . 2008,第1期

机译：大规模平行的亚硫酸氢盐焦磷酸测序揭示了从组织和血清DNA获得的乳腺癌相关胞嘧啶甲基化模式的分子复杂性。
3. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood [J] . Ronn Tina, Volkov Petr, Gillberg Linn, Human Molecular Genetics . 2015,第13期

机译：年龄，BMI和HbA1c水平对人脂肪组织中全基因组DNA甲基化和mRNA表达模式的影响以及血液中表观遗传生物标志物的鉴定
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Effect of Maternal Dietary B-Vitamin Intake on Offspring DNA Methylation Patterns, Gene Expression, Cytokinetics, and Intestinal Tumorigenesis in the Apc+/1638N Mouse Model. [D] . Ciappio, Eric D. 2011

机译：母体饮食中维生素B摄入对Apc + / 1638N小鼠模型中后代DNA甲基化模式，基因表达，细胞动力学和肠道肿瘤发生的影响。
6. Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA [O] . Yulia Korshunova, Rebecca K. Maloney, Nathan Lakey, 2008

机译：大规模平行的亚硫酸氢盐焦磷酸测序揭示了从组织和血清DNA获得的乳腺癌相关胞嘧啶甲基化模式的分子复杂性
7. Reduced representation bisulphite sequencing of ten bovine somatic tissues reveals DNA methylation patterns and their impacts on gene expression [O] . 2016

机译：十个牛体细胞组织的亚硫酸氢盐递减表示法揭示了DNA甲基化模式及其对基因表达的影响

Reduced representation bisulphite sequencing of ten bovine somatic tissues reveals DNA methylation patterns and their impacts on gene expression

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