Genome-wide analysis uncovers high frequency strong differential chromosomal interactions and their associated epigenetic patterns in E2-mediated gene regulation

摘要

BackgroundAn emerging Hi-C protocol has the ability to probe three-dimensional (3D) architecture and capture chromatin interactions in a genome-wide scale. It provides informative results to address how chromatin organization changes contribute to disease/tumor occurrence and progression in response to stimulation of environmental chemicals or hormones.