Functional genomics of pH homeostasis in Corynebacterium glutamicum revealed novel links between pH response oxidative stress iron homeostasis and methionine synthesis

摘要

BackgroundThe maintenance of internal pH in bacterial cells is challenged by natural stress conditions, during host infection or in biotechnological production processes. Comprehensive transcriptomic and proteomic analyses has been conducted in several bacterial model systems, yet questions remain as to the mechanisms of pH homeostasis.