Systems level analysis of two-component signal transduction systems in Erwinia amylovora: Role in virulence regulation of amylovoran biosynthesis and swarming motility

摘要

BackgroundTwo-component signal transduction systems (TCSTs), consisting of a histidine kinase (HK) and a response regulator (RR), represent a major paradigm for signal transduction in prokaryotes. TCSTs play critical roles in sensing and responding to environmental conditions, and in bacterial pathogenesis. Most TCSTs in Erwinia amylovora have either not been identified or have not yet been studied.