Prevalence and determinants of persistent symptoms after treatment for Lyme borreliosis: study protocol for an observational prospective cohort study (LymeProspect)

摘要

BackgroundAfter antibiotic treatment of Lyme borreliosis, a subset of patients report persistent symptoms, also referred to as post-treatment Lyme disease syndrome. The reported prevalence of persistent symptoms varies considerably, and its pathophysiology is under debate. The LymeProspect study has been designed to investigate the prevalence, severity, and a wide range of hypotheses on the etiology of persistent symptoms among patients treated for Lyme borreliosis in the Netherlands.