Mitf-Mdel a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M as a candidate biomarker for melanoma

摘要

BackgroundMelanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient efficacy. Thus, identification of new melanocyte/melanoma antigens that serve as potential novel candidate biomarkers in melanoma is an important area for investigation.