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Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms

机译：德国和日本受试者血清SP-D水平差异与SFTPD基因多态性有关

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摘要

BackgroundSurfactant protein A (SP-A) and SP-D are clinically established in Japan as serum biomarkers for diagnosing interstitial lung diseases (ILDs). Serum SP-D levels are affected by genetic variants. We conducted the present study to examine whether serum SP-A and/or SP-D levels in healthy subjects (HS) and patients with ILDs differ between populations with different genetic backgrounds.

机译：背景技术表面活性剂蛋白A（SP-A）和SP-D在日本临床上被确立为诊断间质性肺病（ILD）的血清生物标志物。血清SP-D水平受遗传变异影响。我们进行了本研究，以检查健康受试者（HS）和ILD患者的血清SP-A和/或SP-D水平在具有不同遗传背景的人群之间是否存在差异。

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期刊名称 BMC Medical Genetics
作者
Yasushi Horimasu; Noboru Hattori; Nobuhisa Ishikawa; Sonosuke Tanaka; Francesco Bonella; Shinichiro Ohshimo; Josune Guzman; Ulrich Costabel; Nobuoki Kohno;
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作者单位

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年(卷),期 2014(15),-1
年度 2014
页码 4
总页数 9
原文格式 PDF
正文语种
中图分类遗传学;
关键词
Biological marker Idiopathic interstitial pneumonia Single nucleotide polymorphism Surfactant protein-A (SP-A) Surfactant protein-D (SP-D);

机译：生物标志物;特发性间质性肺炎;单核苷酸多态性;表面活性剂蛋白A（SP-A）;表面活性剂蛋白D（SP-D）;

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专利

1. Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms [J] . Yasushi Horimasu, Noboru Hattori, Nobuhisa Ishikawa, BMC Medical Genetics . 2014,第1期

机译：德国和日本受试者血清SP-D水平的差异与SFTPD基因多态性有关
2. Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced [J] . Kathrin Heidinger, Inke R. König, Anette Bohnert, Immunogenetics . 2005,第1a2期

机译：人类表面活性剂蛋白D（SFTPD）基因中的多态性：有力证据表明血清表面活性剂蛋白D（SP-D）的水平受到遗传影响
3. Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels [J] . HorimasuY., HattoriN., IshikawaN., Respiratory medicine . 2012,第12期

机译：德国和日本人不同的MUC1基因多态性影响血清KL-6水平
4. Serum Homocysteine Levels and C6671 MTHFR Gene Polymorphism in Patients Type 2 Diabetes [C] . B. Idzior Walus, M. Sanak, M. Walus, International Congress on Coronary Artery Disease . 2003

机译：患者2型糖尿病中的血清同型半胱氨酸水平和C6671 MTHFR基因多态性
5. High degree of genetic polymorphism in apolipoprotein(a) associated with plasma lipoprotein(a) levels in Japanese and Chinese populations [D] . Kikuchi Syuuichi 1994

机译：日本和中国人群中载脂蛋白（a）与血浆脂蛋白（a）水平相关的高度遗传多态性
6. Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced [O] . Kathrin Heidinger, Inke R. König, Anette Bohnert, -1

机译：人类表面活性剂蛋白D（SFTPD）基因中的多态性：有力证据表明血清表面活性剂蛋白D（SP-D）的水平受到遗传影响
7. Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms [O] . Horimasu, Yasushi, Hattori, Noboru, Ishikawa, Nobuhisa, 2014

机译：德国和日本受试者血清SP-D水平差异与SFTPD基因多态性有关

Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms

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