Maternal angiotensinogen (AGT) haplotypes fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data

摘要

BackgroundPreeclampsia is a debilitating disorder affecting approximately 3% of pregnant women in the Western world. Although inconclusive, current evidence suggests that the renin-angiotensin system may be involved in hypertension. Therefore, our objective was to determine whether the genes for placental renin (REN) and maternal angiotensinogen (AGT) interact to influence the risk of preeclampsia.