A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials

摘要

BackgroundWhen investigating subgroup effects in meta-analysis, it is unclear whether accounting in meta-regression for between-trial variation in treatment effects, but not between-trial variation in treatment interaction effects when such effects are present, leads to biased estimates, coverage problems, or wrong standard errors, and whether the use of aggregate data (AD) or individual-patient-data (IPD) influences this assessment.