Identification of the replication region in pBCNF5603 a bacteriocin-encoding plasmid in the enterotoxigenic Clostridium perfringens strain F5603

摘要

BackgroundMost recent studies of Clostridium perfringens plasmids have focused on toxin-encoding or antibiotic resistance plasmids. To cause intestinal disease, a toxigenic strain must grow in the intestines to levels allowing for sufficient toxin production and this in vivo growth often involves overcoming the normal intestinal microbial population. For this purpose, bacteriocin production might be important.