Chlamydia trachomatis responds to heat shock penicillin induced persistence and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA

摘要

BackgroundChlamydia trachomatis, an obligate intracellular human pathogen, is the most prevalent bacterial sexually transmitted infection worldwide and a leading cause of preventable blindness. HtrA is a virulence and stress response periplasmic serine protease and molecular chaperone found in many bacteria. Recombinant purified C. trachomatis HtrA has been previously shown to have both activities. This investigation examined the physiological role of Chlamydia trachomatis HtrA.