Maternal overweight is not an independent risk factor for increased birth weight leptin and insulin in newborns of gestational diabetic women: observations from the prospective ‘EaCH’ cohort study

摘要

BackgroundBoth gestational diabetes mellitus (GDM) as well as overweight/obesity during pregnancy are risk factors for detrimental anthropometric and hormonal neonatal outcomes, identified to ‘program’ adverse health predispositions later on. While overweight/obesity are major determinants of GDM, independent effects on critical birth outcomes remain unclear. Thus, the aim of the present study was to evaluate, in women with GDM, the relative/independent impact of overweight/obesity vs. altered glucose metabolism on newborn parameters.