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美国卫生研究院文献>BMC Pregnancy and Childbirth
>Subgroup identification of early preterm birth (ePTB): informing a future prospective enrichment clinical trial design
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Subgroup identification of early preterm birth (ePTB): informing a future prospective enrichment clinical trial design
BackgroundDespite the widely recognized association between the severity of early preterm birth (ePTB) and its related severe diseases, little is known about the potential risk factors of ePTB and the sub-population with high risk of ePTB. Moreover, motivated by a future confirmatory clinical trial to identify whether supplementing pregnant women with docosahexaenoic acid (DHA) has a different effect on the risk subgroup population or not in terms of ePTB prevalence, this study aims to identify potential risk subgroups and risk factors for ePTB, defined as babies born less than 34 weeks of gestation.
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