Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12427-list-0001">The present study demonstrates that electromyograms (EMGs) obtained during locomotor activity in mice were effective for identification of early physiological markers of amyotrophic lateral sclerosis (ALS). These measures could be used to evaluate therapeutic intervention strategies in animal models of ALS.Several parameters of locomotor activity were shifted early in the disease time course in SOD1G93A mice, especially when the treadmill was inclined, including intermuscular phase, burst skew and amplitude of the locomotor bursts.The results of the present study indicate that early compensatory changes may be taking place within the neural network controlling locomotor activity, including spinal interneurons.Locomotor EMGs could have potential use as a clinical diagnostic tool.