Thyroid hormone activation by type 2 deiodinase mediates exercise‐induced peroxisome proliferator‐activated receptor‐γ coactivator‐1α expression in skeletal muscle

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp7373-list-0001">In skeletal muscle, physical exercise and thyroid hormone mediate the peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1a) expression that is crucial to skeletal muscle mitochondrial function.The expression of type 2 deiodinase (D2), which activates thyroid hormone in skeletal muscle is upregulated by acute treadmill exercise through a β‐adrenergic receptor‐dependent mechanism.Pharmacological block of D2 or disruption of the Dio2 gene in skeletal muscle fibres impaired acute exercise‐induced PGC‐1a expression. Dio2 disruption also impaired muscle PGC‐1a expression and mitochondrial citrate synthase activity in chronically exercised mice.