A nuclear factor-binding domain in the 5-untranslated region of the amyloid precursor protein promoter: Implications for the regulation of gene expression

摘要

BackgroundThe extracellular deposition of aggregated amyloid β-protein is a neuropathological manifestation of Alzheimer disease and Down syndrome. The Amyloid β-protein is derived from a group of larger differentially spliced proteins, the amyloid protein precursors (APP). Data suggests that the level of APP gene expression could contribute to the pathological processes leading to amyloid depositions.