REGULATION OF AMYLOID PRECURSOR PROTEIN EXPRESSION BY MODIFICATION OF ABC TRANSPORTER EXPRESSION OR ACTIVITY

摘要

The invention relates to the discovery that expression of amyloid precursor protein is regulated by the expression of an ABC transporter. The invention therefore provides methods and compositions for modulating amyloid precursor protein expression in a brain cell, thereby preventing or inhibiting pathological beta -amyloid plaque formation in conditions such as Alzheimer's disease.