Sig2GRN: a software tool linking signaling pathway with gene regulatory network for dynamic simulation

摘要

BackgroundLinking computational models of signaling pathways to predicted cellular responses such as gene expression regulation is a major challenge in computational systems biology. In this work, we present Sig2GRN, a Cytoscape plugin that is able to simulate time-course gene expression data given the user-defined external stimuli to the signaling pathways.