Unexpected outcome (positive or negative) including adverse drug reactions: My legs are getting old: sinvastatin-induced polyneuropathy

摘要

Axonal degeneration is the most common type of neuropathy induced by medication. The literature describes isolated cases in which polyneuropathy of the lower limb was observed during treatment with statins.The authors present a case of polyneuropathy associated with the use of a statin. An 82-year-old female patient presented with a complaint of weakness and discomfort in her lower limbs after 7 years of therapy with simvastatin. The results of an electromyographic study were compatible with polyneuropathy (sensorimotor axonal neuropathy – moderate to severe). One month after the therapy with simvastatin was discontinued, the symptoms were reduced.