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Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children- a medical center experience

机译：丙戊酸盐和奥卡西平对癫痫儿童生长速度和骨代谢的潜在影响-医学中心的经验

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摘要

BackgroundChildren with longstanding use of antiepileptic drugs (AEDs) are susceptible to developing low bone mineral density and an increased fracture risk. However, the literature regarding the effects of AEDs on growth in epileptic children is limited. The aim of this study was to investigate the potential effects of valproate (VPA) and/or oxcarbazepine (OXC) therapy on growth velocity and bone metabolism.

机译：背景长期使用抗癫痫药（AED）的儿童容易出现低骨矿物质密度并增加骨折风险。但是，有关AED对癫痫儿童生长的影响的文献有限。这项研究的目的是研究丙戊酸盐（VPA）和/或奥卡西平（OXC）治疗对生长速度和骨代谢的潜在影响。

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期刊名称 BMC Pediatrics
作者
Chien-Ming Lin; Hueng-Chuen Fan; Tsu-Yi Chao; Der-Ming Chu; Chi-Chieh Lai; Chih-Chien Wang; Shyi-Jou Chen;
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作者单位

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年(卷),期 2016(16),-1
年度 2016
页码 61
总页数 6
原文格式 PDF
正文语种
中图分类儿科学;
关键词
Antiepileptic drugs Growth velocity Bone metabolism Tartrate-resistant acid phosphatase 5b Bone-specific alkaline phosphatase;

机译：抗癫痫药;生长速度;骨代谢;抗酒石酸酸性磷酸酶5b;骨特异性碱性磷酸酶;

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1. Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children- a medical center experience [J] . Chien-Ming Lin, Hueng-Chuen Fan, Tsu-Yi Chao, BMC Pediatrics . 2016,第1期

机译：丙戊酸盐和奥卡西平对癫痫儿童生长速度和骨代谢的潜在影响-医学中心的经验
2. First Analysis of the Association Between CYP3A4/5, ABCB1 Genetic Polymorphisms and Oxcarbazepine Metabolism and Transport in Chinese Epileptic Patients with Oxcarbazepine Monotherapy and Bitherapy [J] . Wang Ping, Yin Tao, Ma HongYing, Journal of Pharmacy and Pharmaceutical Sciences . 2015,第3期

机译：首次分析CYP3A4 / 5，ABCB1遗传多态性与牛毒毒素患者的氧盲虫单药治疗和脑梗死患者的交通
3. Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine [J] . CansuA., SerdarogluA., BiberogluG., Epileptic disorders: international epilepsy journal with videotape . 2011,第4期

机译：串联质谱法分析丙戊酸盐和奥卡西平致癫痫儿童的酰基肉碱水平
4. Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats [C] . Atsushi Takahashi, Kenji Onodera, Takashi Sait International Symposium for Interface Oral Health Science . 2005

机译：抗癫痫素，Zonisamide和Valproate对生长大鼠骨代谢的影响
5. Exploration of the Independent and Combined Effects of Energy and Estrogen on Bone Metabolism, Bone Structure, and Estimated Bone Strength in Young Exercising Women [D] . Southmayd, Emily Anne. 2019

机译：探讨能量和雌激素对骨代谢，骨结构和估计骨骼强度的骨骼促进妇女的探讨
6. A double-blind placebo-controlled interaction study between oxcarbazepine and carbamazepine sodium valproate and phenytoin in epileptic patients. [O] . P J McKee, J Blacklaw, G Forrest, 1994

机译：奥卡西平与卡马西平丙戊酸钠和苯妥英钠在癫痫患者中的双盲安慰剂对照相互作用研究。
7. Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children- a medical center experience [O] . Chien-Ming Lin, Hueng-Chuen Fan, Tsu-Yi Chao, 2016

机译：丙戊酸盐和奥卡西平对癫痫儿童生长速度和骨代谢的潜在影响-医学中心的经验
8. Collaborative Research and Support of Fitzsimmons Army Medical Center DWHResearch Program Projects. The Effects of Region-Specific Resistance Exercises on Bone Mass in Premenopausal Military Women, Protocol 8 [R] . Hayes, R. L., Bennion, S., McDermott, M. T. 1995

机译：Fitzsimmons陆军医疗中心DWHResearch计划项目的合作研究和支持。区域特异性阻力训练对绝经前军人妇女骨量的影响，议定书8

Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children- a medical center experience

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