A self-propelling colonoscopic device moving inside the colonic tube should be able to periodically grip safely to the colonic wall as well as to manipulate the generated friction. The feasibility of achieving high grip and friction manipulation by covering the device with mucoadhesive films is experimentally tested. More precisely, the frictional behaviour of mucoadhesive films inside the colonic tube is tested in vitro in porcine colon. It appears that mucoadhesive films generate significantly higher friction than conventional materials (ANOVA p=0, 95% CIs=−3.04, −2.14). The geometry of the film plays a role as well. When holes are, for instance, present in the film geometry and are large enough so that the colonic tissue can wrap their borders, friction can be significantly increased (ANOVA p=0, 95% CIs=−2.53, −1.26). By altering the contact area or the film geometry, friction manipulation can be achieved. Moreover, a simple theoretical model is developed and experimentally verified (R=0.92). The model can be used to estimate the level of the friction generated by three-dimensional configurations of mucoadhesive films as a function of their geometric characteristics and the material properties of the colon.
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机译:在结肠管内移动的自推进结肠镜设备应能够定期安全地夹在结肠壁上,并能操纵产生的摩擦。通过用粘膜粘附膜覆盖装置来实现高抓地力和摩擦操纵的可行性已通过实验测试。更精确地,在猪结肠中体外测试结肠管内粘膜粘附膜的摩擦行为。似乎粘膜粘附膜产生的摩擦力比传统材料高得多(ANOVA p = 0,95%CIs = -3.04,-2.14)。影片的几何形状也起作用。例如,当膜的几何形状中存在孔且孔足够大以至于结肠组织可以包裹其边界时,摩擦力可能会大大增加(ANOVA p = 0,95%CIs = -2.53,-1.26)。通过改变接触面积或膜的几何形状,可以实现摩擦操纵。此外,开发了一个简单的理论模型并进行了实验验证(R = 0.92)。该模型可用于估计由粘膜粘附膜的三维结构产生的摩擦力水平,这些摩擦力是膜的几何特征和结肠材料特性的函数。
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