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Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents

机译：小分子MIRA-1诱导体外和体内抗骨髓瘤活性并与目前的抗骨髓瘤药物协同作用

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Background: Small molecule MIRA-1 induced mutant p53-dependent apoptosis in several types of solid tumours. However, anti-tumour activity of MIRA-1 in haematological malignancies including multiple myeloma (MM) is unknown. In this study, we evaluated the effect of MIRA-1 in MM.

机译：背景：小分子MIRA-1在几种类型的实体瘤中诱导突变型p53依赖性细胞凋亡。然而，MIRA-1在包括多发性骨髓瘤（MM）在内的血液系统恶性肿瘤中的抗肿瘤活性尚不清楚。在这项研究中，我们评估了MIRA-1在MM中的作用。

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期刊名称 British Journal of Cancer
作者
M N Saha; Y Chen; M-H Chen; G Chen; H Chang;
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作者单位

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年(卷),期 2014(110),9
年度 2014
页码 2224–2231
总页数 8
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
myeloma MIRA p53 apoptosis;

机译：骨髓瘤;MIRA;p53;细胞凋亡;

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专利

1. Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents [J] . M N Saha, Y Chen, M-H Chen, British Journal of Cancer . 2014,第9期

机译：小分子MIRA-1诱导体外和体内抗骨髓瘤活性并与目前的抗骨髓瘤药物协同作用
2. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. [J] . Kim K, Kong SY, Fulciniti M, British Journal of Haematology . 2010,第4期

机译：新型选择性MEK1 / 2抑制剂AS703026对MEK / ERK信号级联反应的阻断可在体内和体外诱导多效性抗骨髓瘤活性。
3. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo [J] . Kihyun Kim, Sun-Young Kong, Mariateresa Fulciniti, British Journal of Haematology . 2010,第4期

机译：新型选择性MEK1 / 2抑制剂AS703026对MEK / ERK信号级联的阻断可在体内和体外诱导多效性抗骨髓瘤活性
4. COMPATATION STUDY OF ESTROGENIC-ACTIVITY INDUCED BY FOUR TYPICAL CHEMICALS USING in vivo AND in vitro METHODS [C] . Song Maoyong, Lv Xuefei, Shao Jing, International symposium on halogenated persistent organic pollutants . 2009

机译：四种典型化学物质体内和体外诱导雌激素活性的比较研究
5. Raman optical activity: Theory, instrumentation and measurements. Electron transition current density: Ab initio calculation of vibrational transition current density in selected molecules. [D] . Lee, Eunah. 2000

机译：拉曼光学活性：理论，仪器和测量。电子跃迁电流密度：所选分子中振动跃迁电流密度的从头算。
6. Blockade of the MEK/ERK signaling cascade by AS703026 a novel selective MEK1/2 inhibitor induces pleiotropic anti-myeloma activity in vitro and in vivo [O] . Kihyun Kim, Sun-Young Kong, Mariateresa Fulciniti, -1

机译：通过AS703026封锁MEK / ERK信号级联一种新颖的选择性MEK1 / 2抑制剂在体外和体内诱导抗血液抗骨髓瘤活性
7. The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo [O] . Liang Zhou, Yu Zhang, Yun Leng, 2019

机译：IAP拮抗剂Birinapant在体外和体内增强硼替佐米抗骨髓瘤活性

Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents

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