Lapatinib monotherapy in patients with relapsed advanced or metastatic breast cancer: efficacy safety and biomarker results from Japanese patients phase II studies

摘要

Background: HER2-positive metastatic breast cancer (MBC) relapsing after trastuzumab-based therapy may require continued HER2 receptor inhibition to control the disease and preserve the patients' quality-of-life. Efficacy and safety of lapatinib monotherapy was evaluated in Japanese breast cancer patients after trastuzumab-based therapies.