Sex differences in the acetylcholine receptor kinetics of postnatal and denervated rat muscle

摘要

class="enumerated" style="list-style-type:decimal">Single-channel recording from visualised endplates in freshly dissociated muscles from postnatal and denervated rat muscle revealed the presence of a low conductance, fetal type of acetylcholine receptor.Kinetic analysis showed a main component in the burst durations with a mean of 10.8 ± 2.7 ms (n = 29). Receptors from female rats had an additional 27.3 ± 5.5 ms (n = 5) kinetic component which was found in one-third of the 15 female endplates.Recordings from male and female denervated muscles gave more homogeneous kinetics with single time constants of 7.2 ± 1.3 and 7.4 ± 1.3 ms, respectively.It is concluded that the acetylcholine receptor channels present during early development are different from those of denervated muscle.