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Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat

机译:一氧化氮释放神经在调节大鼠眼血流量中的可能作用

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摘要

AIM—To investigate the role of nitrergic nerves in the regulation of ocular blood flow.
METHODS—Conscious, lightly restrained rats were treated with either the neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI), or the non-selective inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), and ocular blood flow was measured ex vivo from tissue samples, using the fully quantitative [14C]-iodoantipyrine technique.
RESULTS—In the peripheral circulation, L-NAME produced an increase in arterial blood pressure (+22%) while 7-NI had no effect. In contrast, both 7-NI and L-NAME produced significant decreases in ocular blood flow (−31% and −59% respectively). The ocular vascular resistance calculated from ocular blood flow and mean arterial blood pressure increased by 29% following 7-NI, but by 130% following L-NAME.
CONCLUSIONS—Nitric oxide releasing neurons may play an important contributory role in regulating ocular blood flow.

Keywords: nitric oxide; neuronal nitric oxide synthase; 7-nitroindazole; NG-nitro-L-arginine methyl ester; ocular blood flow
机译:目的—研究硝化神经在调节眼部血流中的作用。选择性抑制剂,NG-硝基-L-精氨酸甲酯(L-NAME)和组织全血样品的眼血流量,使用了完全定量的[14C]-碘安替比林技术。
结果—外周循环中,L-NAME使动脉血压升高(+ 22%),而7-NI无影响。相反,7-NI和L-NAME均导致眼血流量显着下降(分别为-31%和-59%)。由眼流量和平均动脉压计算得出的眼血管阻力在7-NI后增加了29%,但在L-NAME后增加了130%。
结论—释放一氧化氮的神经元可能在调节中起重要作用

关键词:一氧化氮;神经元一氧化氮合酶; 7-硝基吲唑; NG-硝基-L-精氨酸甲酯;眼血流量

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