AIM--To determine the relation between epithelial hyperplasia and regression of effect after photorefractive keratectomy (PRK). METHODS--Seventy unilaterally treated patients with PRK were examined. All eyes had been treated with the Summit excimer laser 27 (SD 7) months previously with zone diameters of 4.1 to 5.0 mm. The untreated fellow eyes served as controls. Epithelial thickness was measured centrally with a thin slit optical pachometer and manifest subjective refraction was performed. RESULTS--The epithelium was 21% thicker in the treated eye (p < 0.0001). The relation between refractive regression and epithelial hyperplasia was significant (r = 0.41; p < 0.001). CONCLUSIONS--Epithelial hyperplasia after PRK correlated with the myopic shift (including hyperopia reduction) after treatment with the Summit laser. A model is proposed suggesting that both subepithelial and epithelial layers contribute to regression in the Summit treated eyes with 18 microns of epithelial hyperplasia contributing each dioptre of regression.
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机译：目的-确定光折射性角膜切除术（PRK）后上皮增生与效果消退之间的关系。方法-检查了70例单侧治疗的PRK患者。 27个月前用Summit准分子激光治疗所有眼睛，区域直径为4.1至5.0 mm。未经处理的同伴眼睛作为对照。用薄缝光学转速计在中心测量上皮厚度，并进行主观验光。结果-经治疗的眼睛的上皮细胞厚21％（p <0.0001）。屈光退化与上皮增生之间的关系很明显（r = 0.41； p <0.001）。结论：PRK后上皮增生与Summit激光治疗后的近视移位（包括减少远视）有关。提出了一种模型，该模型表明上皮下层和上皮层均有助于经Summit治疗的18微米上皮增生的眼睛的消退，从而使每个屈光度降低。
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