1. The effect of osmolality and carbohydrate content on the rate of gastric emptying was assessed by using the double sampling gastric aspiration technique to measure the rate of gastric emptying of isoenergetic and isosmotic solutions of glucose and glucose polymer. Six healthy male subjects were each studied on four separate occasions using a test drink volume of 600 ml. 2. The half-emptying time (t1/2, mean +/- S.E.M.) for a dilute (40 g l-1) solution of glucose (LG, 230 mosmol kg-1) was 17 +/- 1 min. This was greater than that (14 +/- 1 min) for a glucose polymer solution with the same energy content (LP, 42 mosmol kg-1). A concentrated (188 g l-1) glucose polymer solution (HP, 237 mosmol kg-1) emptied faster (t1/2 = 64 +/- 8 min) than the corresponding isoenergetic glucose solution (HG, 1300 mosmol kg-1, t1/2 = 130 +/- 18 min). 3. The dilute (40 g l-1) glucose solution emptied faster than the concentrated (188 g l-1) glucose polymer solution with the same osmolality (LG, 230 mosmol kg-1; HP, 237 mosmol kg-1). 4. The two dilute solutions (40 g l-1) delivered a similar amount of carbohydrate to the small intestine, whereas the concentrated (188 g l-1) glucose polymer solution delivered a greater amount of carbohydrate at 20, 40 and 50 min than the isoenergetic glucose solution. 5. These results indicate that both osmolality and carbohydrate content influence gastric emptying of liquids in man, but the carbohydrate content appears to have greater influence than osmolality.(ABSTRACT TRUNCATED AT 250 WORDS)
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机译:1.通过使用双采样胃抽吸技术评估葡萄糖和葡萄糖聚合物的等能量和等渗溶液的胃排空率,评估了重量克分子渗透压浓度和碳水化合物含量对胃排空率的影响。六个健康的男性受试者分别在四个不同的场合使用600毫升的测试饮料进行研究。 2.葡萄糖(LG,230 mosmol kg-1)的稀溶液(40 g l-1)的半排空时间(t1 / 2,平均+/- S.E.M.)为17 +/- 1分钟。这大于具有相同能量含量(LP,42 mosmol kg-1)的葡萄糖聚合物溶液(14 +/- 1分钟)。浓缩的(188 g l-1)葡萄糖聚合物溶液(HP,237 mosmol kg-1)排空(t1 / 2 = 64 +/- 8分钟)比相应的等能葡萄糖溶液(HG,1300 mosmol kg-1, t1 / 2 = 130 +/- 18分钟)。 3.与相同重量克分子渗透压浓度(LG,230 mosmol kg-1; HP,237 mosmol kg-1)相比,稀(40 g l-1)葡萄糖溶液的排空速度快于浓缩(188 g l-1)葡萄糖聚合物溶液的排空速度。 4.两种稀溶液(40 g l-1)向小肠输送相似量的碳水化合物,而浓缩(188 g l-1)葡萄糖聚合物溶液在20、40和50分钟时输送更多的碳水化合物比等能量葡萄糖溶液5.这些结果表明,摩尔渗透压浓度和碳水化合物含量均会影响人体胃液的排空,但碳水化合物含量似乎比摩尔渗透压浓度具有更大的影响。(摘要截断为250字)
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